Highly accurate noninvasive prenatal testing (NIPT)

非侵入性母血胎兒染色體篩檢

Verify Prenatal Test以先進的全基因巨量片段定序(massively parallel sequencing), 提高檢測的敏感度 (sensitivity) 及專一性 (specify), 提供可靠, 精確的檢測結果.

The verifi Prenatal Test takes advantage of deep massively parallel sequencing across the genome, to provide clearer resolution for highly sensitive and specific answers.
懷孕十周即可進行篩檢,抽一次血,可篩檢三種最常發生的體染色體異常及性染色體異常,失敗率低,檢體送到實驗室之後3-5個工作天即可拿到報告


illumina verifi Prenatal Test (NIPT) 檢測效果



1
 Bhatt, S et al. (2014) Clinical Laboratory Experience with Noninvasive Prenatal Testing: Update on Clinically Relevant Metrics ISPD poster.
2 Verinata Health, Inc. (2012) Analytical Validation of the verifi Prenatal Test: Enhanced Test Performance For Detecting Trisomies 21, 18 and 13 and the Option for Classification of Sex Chromosome Status. Redwood City, CA.
3 For test metrics from the MELISSA validation study, please see Bianchi DW, Platt LD, Goldberg JD, et al. Genome-wide fetal aneuploidy detection by maternal plasma DNA sequencing. Obstet Gynecol. 2012:119:890-901. In accordance with medical societies’ requests, the observed metrics shown are provided to reflect more recent clinical experience.

雙胞胎妊娠篩檢
 Screening twin pregnancies

篩檢雙胎妊娠的染色體異常是一項獨特的挑戰所遭遇的困難例如有每一個胎兒能被分析的游離DNA數量不多,或胎兒DNA品質不佳等藉由擴展分析敏感度及分析能力,Illumina verifi Prenatal Test 也可使用在雙胞胎妊娠染色體異常篩檢,如T21、T18、T13及Y染色體的有無。無論是同卵雙胞胎或是異卵雙胞胎都可以進行篩檢。

Illumina verifi Prenatal Test 在工作流程及生物資訊演算的創新發展,改善了檢測非整倍體樣本(aneuploidy-affected samples) 的精準度,使用Illumina特有的演算方法分析115個懷有雙胞胎的母血樣本,有染色體異常的檢體都能正確的被偵測出來。
  • 3/3 cases with T21 present in one twin
  • 1/1 case with T18 present in both twins (monochorionic)
  • 91/91 cases with at least one male twin
  • No false positives reported in this data set.

4Verinata Health, Inc (2012) Accurate Aneuploidy Detection in Twin Pregnancies with an Optimized Algorithm for the verifi Prenatal Test. Redwood City, CA.

檢驗流程



** 若有任何疑問或需要,歡迎您來電洽詢,我們會有專人協助您了解illumina NIPT產品  
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Illumina verifi Prenatal Test (NIPT)產品特色
  • 篩檢 T21 (唐氏症)、T18 (愛德華氏症)、T13 (巴陶氏症)
  • 篩檢單胞胎單套X染色體
  • 篩檢雙胞胎單一Y染色體有無
  • 其他非整倍體染色體異常及染色體微小缺失也都能篩檢

** verifi Prenatal Test 是由Illumina 旗下的Verinata Health 公司所研發及最佳化。Verinata實驗室是通過美國臨床實驗室法規最高標準的認證實驗室,但尚未通過美國食品藥物管理局的認證。

相關影片

2015
1. Noninvasive prenatal testing (NIPT) helps reduce the need for invasive procedures
2. Utilizing NIPT in a maternal-fetal medicine practice: Dr. Martin Chavez

2013
1. Integrating Noninvasive DNA Testing (NIDT) into the Prenatal Testing Paradigm by Dr. Bianchi

相關文獻資料

2015

1. Clinical laboratory experience with noninvasive prenatal testing in twin gestations 
2. DNA Sequencing versus Standard Prenatal Aneuploidy Screening
3. 
An MFM's Perspective on NIPT

2014
1. 
Fetal Sex Chromosome Testing by Maternal Plasma DNA Sequencing

 ** 若有任何疑問或需要,歡迎您來電洽詢,我們會有專人協助您了解illumina NIPT 產品
 ** 若您及技術團隊想更進一步了解技術原理,我們也能配合貴院所的時間到府詳細介紹、說明
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For research use only. Not for in vitro diagnostic use.
以上資料來源為 Illumina 官方網站